What is GLP-1?
GLP-1 (glucagon-like peptide-1) is a naturally occurring hormone released in the small intestine that plays a key role in appetite control, satiety, blood sugar balance, and metabolic health. It stimulates the release of insulin, reduces the release of glucagon (a hormone that raises blood sugar), and helps slow digestion.
How Do GLP-1 Medications Help with Weight Loss?
The recent development of GLP-1 weight-loss medications are typically used for managing type 2 diabetes and obesity. They work by mimicking the body’s natural GLP-1 hormone produced by the small intestine that helps trigger insulin release to help manage blood sugar. These medications have been shown to slow digestion and increase satiety, helping you feel fuller longer and potentially reduce your overall food consumption. This process contributes to weight loss, especially when paired with diet and exercise. 1
Research on GLP-1 Medications and Supplements
Current research shows that GLP-1 medications can contribute to lower food intake and cause patients to eat fewer calories overall. With lowered food consumption, it’s important for individuals on GLP-1 medications to consume nutrient-rich foods to ensure they are meeting their micronutrient needs. Support from a balanced diet and additional vitamin and mineral supplementation can be beneficial in this effort. Supplements should be viewed as supporting a healthy diet rather than replacing nutrients. 2
How Does Nutrition Support GLP-1?
While GLP-1 medications have gained attention, many people are looking for ways to support their body’s own natural GLP-1 production through nutrition and targeted supplementation. Research shows that diet quality—especially protein, fiber, and healthy fats—can influence GLP-1 activity. 2
Protein
High-protein foods such as eggs, lean meats, fish, dairy, and whey protein are powerful natural stimulators of GLP-1 release. Protein is broken down into amino acids and peptides during digestion, which directly signal intestinal L-cells to release GLP-1. This release contributes to the feeling of increased fullness, reduced cravings, and can support post-meal blood sugar control. 3
Fiber
Soluble and fermentable fibers—found in oats, legumes, fruits, and vegetables—feed beneficial gut bacteria. As these fibers ferment, they produce short-chain fatty acids (SCFAs), which act as key messengers that encourage GLP-1 secretion. Fiber also slows digestion, supporting prolonged satiety. 4
Healthy Fats
Monounsaturated fats (olive oil, avocados) and omega-3 fatty acids (fatty fish, nuts) can help slow gastric emptying, which may result in more effective GLP-1 release than with saturated fats, thereby supporting appetite and metabolic balance.5
How Sisel Products Fit Into GLP-1 Support
Our Sisel health and fitness products are formulated with clean, natural ingredients designed to support balanced metabolism, gut health, and steady blood sugar levels, which are all factors known to help the body’s own GLP-1 secretion and incretin (the metabolic hormones that decrease blood glucose levels) responses after meals.
SiseLEAN™ Weight Management Shake
SiseLEAN delivers 12 grams of premium protein (whey, milk, and pea) plus 4 grams of fiber in a low-calorie serving. Protein is a positive GLP-1 stimulator, while fiber enhances fermentation in the intestine. Together, this combination of ingredients supports satiety, craving control, and stable energy—hallmarks of healthy GLP-1 activity.
SiselGUT Essentials™ Daily Pre & Probiotic
This advanced product provides a strong foundation for indirect GLP-1 support. With 10 probiotic strains (35 billion CFUs at manufacturing), four unique prebiotics, and apple fiber, SiselGUT Essentials Daily Pre & Probiotic is designed to help nourish a healthy gut microbiome. A balanced microbiome produces SCFAs during fiber fermentation—an important trigger for GLP-1 release. Improved gut health can also support digestion, fullness, and metabolic signaling.
SiselGUT Essentials™ Digestive Enzyme Support
Efficient digestion plays a critical role in GLP-1 activation, as GLP-1 release is stimulated by the breakdown of food into amino acids, fatty acids, and other signaling molecules. SiselGUT Essentials Digestive Enzyme Support aids the proper digestion of proteins, carbohydrates, and fats, helping ensure nutrients are fully broken down and absorbed. Improved protein digestion can enhance the availability of GLP-1–stimulating amino acids, while better fat digestion supports healthy gastric emptying and satiety signals. For individuals eating smaller meals, optimal digestion becomes even more important to maximize nutritional impact and metabolic signaling.
GLUCOminish™ Blood Sugar Support
Formulated primarily for blood sugar balance and fat metabolism support, GLUCOminish complements GLP-1 nutrition by encouraging stable glucose levels and reduced cravings. These downstream benefits are commonly associated with higher GLP-1 signaling, making this product a supportive addition when used alongside protein- and fiber-rich options.
TRIMogenic™ Full Spectrum Weight Loss
TRIMogenic stands out for its inclusion of berberine, a compound studied for its ability to indirectly enhance natural GLP-1 secretion through gut microbiome modulation and improved glucose metabolism support. Berberine may also support insulin sensitivity and fat breakdown—processes closely linked to GLP-1 pathways—making this a strong natural support option. 6
SiselRIPT™ Pro-Grade Post-Workout
SiselRIPT provides amino acids that directly stimulate endogenous GLP-1 release. Research shows that certain amino acids—especially glutamine, valine, arginine, phenylalanine, and tryptophan—are powerful GLP-1 activators. 7 Glutamine, in particular, has been seen to demonstrate dramatic increases in GLP-1 secretion in cell models. By supplying these amino acids, SiselRIPT supports feelings of satiety, metabolic signaling, and workout-driven fat utilization.
SupraOmega PLUS™ with Crystal-Free CoQ10
This comprehensive omega fatty acid blend (3, 5, 6, 7, and 9), along with CoQ10 and vitamin E, offers the healthy fats that can support natural GLP-1 release. Omega-3s and omega-7s have been shown to help slow digestion and support healthy blood sugar and metabolism, reinforcing GLP-1’s appetite-regulating effects. 8
Sisel Encompass 360™ Advanced Multi-Vitamin and Multi-Mineral
When GLP-1 activity is higher, appetite decreases naturally —and for many people that means eating fewer calories overall. While GLP-1 activity supports weight management, it can also increase the risk of missing key vitamins and minerals. Encompass 360™ delivers comprehensive nutritional support with essential vitamins, minerals, antioxidants, and phytonutrients to help fill those gaps. Encompass 360 supports energy, immune health, and metabolic function, making it an important companion to ensure nutritional adequacy while appetite and portion sizes are reduced.
These nutrients found in Encompass 360 are essential for your health 9:
| Vitamins | Minerals |
|---|---|
| Vitamin A: supports immune function, normal vision, cell growth and development. | Calcium: structural component of bones and teeth. |
| Vitamin B6: supports metabolic reactions and assists neurotransmitters, hemoglobin and DNA production. | Chromium: assists insulin action to help process carbohydrates, fats, and proteins. |
| Vitamin B12: assists the release of energy from fat and protein. | Copper: assists energy production and iron utilization. |
| Vitamin C: an antioxidant in blood cells that assists with natural production of collagen, serotonin, carnitine and adrenaline. | Magnesium: required for healthy nerve conduction and muscle contraction. |
| Vitamin D: promotes bone health, immune function and encourages calcium and phosphorous balance. | Manganese: facilitates bone formation and development. |
| Vitamin E: acts as an antioxidant in cell membranes and supports normal nerve function. | Molybdenum: assists in the metabolism of proteins. |
| Vitamin K: assists in blood clotting and allows for calcium binding. | Selenium: influences thyroid hormone function. |
| Thiamin (Vitamin B1), Riboflavin (Vitamin B2), Biotin (Vitamin B7) and Niacin (Vitamin B3): help release energy from fat, carbohydrates and protein. | Sodium: maintains fluid and electrolyte balance. |
| Pantothenic Acid (Vitamin B5): assists in the release of energy from fat, carbohydrates and protein and also assists fat, cholesterol, steroid hormones and hemoglobin synthesis. | Zinc: supports immune function. |
| Folate (Vitamin B19): assists red blood cell production. |
A Natural, Synergistic Approach
Supporting natural GLP-1 production isn’t about a single product—it’s about synergy. A diet rich in protein, fiber, and healthy fats are the foundation for natural GLP-1, and Sisel products such as SiselGUT Essentials Daily Pre and Probiotic, SiseLEAN, GLUCOminish, TRIMogenic, SupraOmega PLUS, SiselRIPT, and Encompass 360 can help support and reinforce the same healthy biological pathways. Together, these products can suppor fullness, balanced blood sugar, and metabolic efficiency—key benefits associated with healthy GLP-1 activity—using nutrition and science your body already understands.
References:
1 GLP-1 Agonists: What They Are, How They Work & Side Effects
4 High protein intake stimulates postprandial GLP1 and PYY release
5 Incretin and islet hormonal responses to fat and protein ingestion in healthy men
7 Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review – PMC
8 Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 – PubMed
9 Micronutrients for Health | Linus Pauling Institute | Oregon State University
- GLP-1 Agonists: What They Are, How They Work & Side Effects
Cleveland Clinic. (2023). GLP-1 agonists: What they are, how they work & side effects. Cleveland Clinic. https://my.clevelandclinic.org/health/treatments/13901-glp-1-agonists - Nutritional considerations with antiobesity medications
Almandoz, J. P., et al. (2024). Nutritional considerations with antiobesity medications. Obesity (Silver Spring). https://onlinelibrary.wiley.com/doi/10.1002/oby.24067?af=R#oby24067-bib-0055 - Adaptation of colonic fermentation and GLP-1 secretion with wheat fibre intake
Freeland, K. R., Wilson, C., & Wolever, T. M. S. (2010). Adaptation of colonic fermentation and glucagon-like peptide-1 secretion with increased wheat fibre intake for 1 year in hyperinsulinaemic human subjects. British Journal of Nutrition, 103(1), 82–90. https://pubmed.ncbi.nlm.nih.gov/19664300/ - High protein intake stimulates postprandial GLP-1 and PYY release
van der Klaauw, A. A., Keogh, J. M., Henning, W., Trowse, V. M., Dhillo, W. S., Ghatei, M. A., et al. (2013). High protein intake stimulates postprandial GLP-1 and PYY release. Obesity (Silver Spring, Md.), 21(8), 1602–1607 . https://pubmed.ncbi.nlm.nih.gov/23666746/ - Incretin and islet hormonal responses to fat and protein ingestion
Carr, R. D., Larsen, M. O., Sörhede Winzell, M., Jelic, K., Lindgren, O., Deacon, C. F., & Ahrén, B. (2008). Incretin and islet hormonal responses to fat and protein ingestion in healthy men. American Journal of Physiology-Endocrinology and Metabolism, 295(4), E779–E784. https://pubmed.ncbi.nlm.nih.gov/18612044/
6a. Effect of berberine on metabolic syndrome, insulin sensitivity, and secretion
Pérez-Rubio, K. G., González-Ortiz, M., Martínez-Abundis, E., & Robles-Cervantes, J. A. (2013). Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Metabolic Syndrome and Related Disorders, 12(10). https://pubmed.ncbi.nlm.nih.gov/23808999/
6b. Efficacy and safety of berberine alone for metabolic disorders: systematic review
— Citation (systematic review & meta-analysis): Author(s). (Year). Efficacy and safety of berberine alone for several metabolic disorders: A systematic review and meta-analysis of randomized clinical trials. Journal Name, Volume(Issue), pages. https://pmc.ncbi.nlm.nih.gov/articles/PMC8107691/
- Protein- and calcium-mediated GLP-1 secretion: A narrative review
— Citation: Author(s). (Year). Protein- and calcium-mediated GLP-1 secretion: A narrative review. Journal Name, Volume(Issue), pages. https://pmc.ncbi.nlm.nih.gov/articles/PMC8634310/
8a. Free fatty acids regulate gut incretin GLP-1 secretion through GPR120
Hirasawa, A., Tsumaya, K., Awaji, T., et al. (2005). Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Diabetes, 54(1), p.??–??. https://pubmed.ncbi.nlm.nih.gov/15619630/
8b. Colonic delivery of DHA improves glucose tolerance via GLP-1 in mice
— Citation: Author(s). (Year). Colonic delivery of docosahexaenoic acid improves impaired glucose tolerance via GLP-1 secretion and suppresses pancreatic islet hyperplasia in diabetic KK-A(y) mice. Journal Name, Volume(Issue), pages. https://pubmed.ncbi.nlm.nih.gov/23618969/
- Micronutrients for Health — Linus Pauling Institute
Meyer, F., et al. (Year). Micronutrients for Health. Linus Pauling Institute, Oregon State University. https://lpi.oregonstate.edu/mic/micronutrients-health
Integrated health solutions, where prescription drugs and nutrition products are marketed in tandem to maximize outcomes reflect a broader trend in health and wellness.