Sisel International is expanding its men’s wellness portfolio with two brand-new products: XYVantage BOOST™ and XYVantage GUARD™. These natural supplements are a complete rethink of how men’s hormonal wellness should be approached, built around a connection much of the market has overlooked.
Two Distinct Solutions for Men’s Hormonal Wellness
XYVantage BOOST is a high-performance formula built to help maintain healthy testosterone levels, strength, endurance, recovery, and motivation. It includes two patented, clinically studied ingredients: TestFACTOR® and KSM-66® Ashwagandha.*
XYVantage GUARD is a comprehensive prostate-support formula built to aid urinary comfort, hormone metabolism, and cellular wellness through a robust blend of natural botanicals. Individually, each formula is a strong, standalone addition to any men’s wellness routine, addressing a distinct area of health on its own.*
Here’s everything you need to know about how each product works, what makes the science behind them compelling, and why each one stands out as a meaningful addition to Sisel’s wellness lineup.
XYVantage BOOST: Built to Support Testosterone, Strength, and Drive
XYVantage BOOST is formulated to help men maintain healthy testosterone levels, strength, endurance, recovery, motivation, and overall vitality. It combines two patented ingredients with a supporting cast of traditional botanicals, all selected to work on different aspects of men’s performance at once rather than relying on a single mechanism.*
TestFactor®: The Clinically Studied Core of the Formula
TestFactor is a patented ingredient included in XYVantage BOOST specifically for its researched role in supporting healthy testosterone levels. In human clinical trials, TestFactor® has been shown to have a beneficial impact on men’s hormone levels and overall health by increasing total serum testosterone by 19%, improving overall sexual function by 48%, boosting sexual satisfaction by 44%, and reducing physical fatigue by 51%.*
Importantly, TestFactor doesn’t introduce hormones into the body. Instead, it’s designed to support the body’s own natural testosterone-production pathway.*
KSM-66 Ashwagandha®: Strength, Recovery, and Stress Resilience
KSM-66 Ashwagandha is one of the most recognized full-spectrum ashwagandha extracts available, and it’s included in XYVantage BOOST to enhance muscle strength, improve endurance, reduce exercise-induced fatigue, and support faster recovery.*
As an adaptogenic botanical, ashwagandha has traditionally been used to help the body adapt to physical and mental stress. This matters in a big way, since stress is one of the biggest disruptors of healthy testosterone production in the first place.*
Fenugreek, Longjack, and Mucuna Pruriens: Rounding Out the Formula
Fenugreek has a long history of traditional use in men’s performance formulas and has been studied for its role in supporting vitality, exercise performance, and motivation. Longjack (Tongkat Ali) has gained attention for its potential to support an active lifestyle by promoting energy, physical performance, and healthy testosterone levels. Mucuna pruriens contains naturally occurring compounds studied for their role in motivation, focus, and mood—a reminder that physical performance and mindset tend to move together.*
Supporting Ingredients
Pomegranate, cayenne pepper, theobromine, and black pepper extract round out the formula. Together, they’re included to support healthy energy levels, nutrient utilization, and overall men’s wellness. They also make it easier for the body to utilize the active ingredients in the XYVantage BOOST formula.*
XYVantage GUARD: Built to Support Prostate Health and Urinary Comfort
As men age, the prostate may naturally change in size, potentially impacting urinary flow, frequency, and everyday comfort. XYVantage GUARD was formulated to support normal prostate function, healthy urinary patterns, hormone metabolism, and cellular wellness through a multi-ingredient blend of botanicals and minerals.*
Saw Palmetto, Pygeum, and Pumpkin Seed Extract: The Prostate-Support Core
Saw palmetto is a well-known and respected ingredient in prostate-support formulas, often discussed in relation to 5-alpha reductase activity—the same enzyme that converts testosterone into DHT.
Pygeum (derived from the bark of the African cherry tree) and pumpkin seed extract balance out this core trio, working together to support normal prostate size and function, comfortable urinary patterns, and healthy nighttime bladder function.*
Plant Sterols, HMR Lignans, and Boron Glycinate: Hormone Metabolism Support
Plant sterols are naturally occurring compounds with anti-inflammatory properties that support normal prostate function and hormone-related pathways. HMR lignans, derived from Norway spruce, are converted by the body into a metabolite called enterolactone, which is involved in hormone-related pathways and cellular health. Boron glycinate, a bioavailable form of the trace mineral boron, helps complete the formula by supporting healthy hormone balance.*
Pomegranate, Grape Seed, Green Tea, and Lycopene: Cellular and Antioxidant Support
Prostate wellness isn’t only about urinary flow—it also depends on a healthy cellular environment. Antioxidant-rich pomegranate, grape seed, green tea, and lycopene are included to help protect cells from oxidative stress, which is a normal part of everyday cellular metabolism and environmental exposure.*
Boswellia Serrata: Comfort Support
Boswellia serrata is a botanical resin traditionally used to support a healthy inflammatory response, rounding out the XYVantage GUARD formula with additional comfort and prostate-wellness support.*
Choosing the Right Support for Where You Are
XYVantage BOOST and XYVantage GUARD were each developed to address a specific area of men’s hormonal wellness on their own. XYVantage BOOST is built for men focused on testosterone support, vitality, and physical performance. XYVantage GUARD is designed to support prostate health, urinary comfort, and cellular wellness.
Because testosterone production and prostate function are part of the same underlying hormonal pathway, some men—particularly those navigating both vitality concerns and age-related prostate changes at once—may find value in incorporating both into their routine. However, each formula is capable of delivering meaningful, complete support for specific men’s health concerns entirely on its own, based on what matters most to you right now.*
Both formulas were developed under Sisel’s internal Sisel Safe® standard for ingredient integrity, quality, and safety—the same standard the company applies across its broader product portfolio.*
How to Use XYVantage BOOST and GUARD
Both supplements are taken the same way: 4 capsules each with 8–16 oz of water once daily. For best results, use consistently as part of a healthy lifestyle that includes resistance training, quality sleep, balanced nutrition, and stress management.*
XYVantage BOOST is not intended for use beyond 90 consecutive days without a two-week break, and it is not intended for women or minors. Men with cardiovascular or prostate conditions, or those taking medication, should consult a healthcare provider before use.*
XYVantage GUARD is intended for adult men only, and we recommend discontinuing use at least two weeks prior to any scheduled surgery, since some ingredients may affect bleeding risk. Anyone with a pre-existing medical condition, or who is taking blood-thinning or other prescription medication, should consult a healthcare provider before starting XYVantage GUARD.*
A Smarter Way to Think About Men’s Hormonal Health
XYVantage BOOST and GUARD are two of the most exciting launches in Sisel’s new men’s wellness portfolio. Each introduces a unique blend of ingredients carefully selected to support men’s hormonal health at various stages of life.*
Whether you’re focused on strength and performance today, prostate and urinary comfort down the road, or building a complete wellness routine that covers both, XYVantage BOOST™ and XYVantage GUARD™ provide a science-backed way to start—and a reason to come back for the long haul.*
Frequently Asked Questions
Why are testosterone support and prostate health connected?
Testosterone is converted in the body by an enzyme called 5-alpha reductase into DHT, a hormone closely tied to prostate function and age-related prostate changes. The same hormonal pathway that drives strength and vitality earlier in life influences prostate health later on.*
Do I need to take both BOOST and GUARD, or can I take just one?
Each formula is designed to work as a standalone product. However, they can be taken together as needed to support a comprehensive men’s wellness routine.*
What’s the key ingredient in XYVantage BOOST?
TestFactor®–a patented, clinically studied ingredient shown to increase total serum testosterone by 19%, improve overall sexual function by 48%, boost sexual satisfaction by 44%, and reduce physical fatigue by 51%.*
What’s the key ingredient in XYVantage GUARD?
Saw palmetto—paired with pygeum and pumpkin seed extract—forms the core of this prostate-support formula, along with plant sterols, HMR lignans, and antioxidant-rich botanicals.
How do I take XYVantage BOOST and GUARD?
Both are taken the same way: 4 capsules with 8–16 oz of water once daily.
Who should not take XYVantage BOOST?
XYVantage BOOST is not intended for women or minors. Men with cardiovascular or prostate conditions, or those taking medication, should consult a healthcare provider before use.*
Who should not take XYVantage GUARD?
XYVantage GUARD is intended for adult men only. Anyone with a pre-existing medical condition or taking blood-thinning or prescription medication should consult a healthcare provider first, and use should be discontinued at least two weeks before any scheduled surgery.*
Does TestFactor introduce hormones into the body?
No. TestFactor is designed to support the body’s own natural testosterone-production pathway rather than introducing external hormones.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
I’ve got my first order in now. Can’t wait to try these new Sisel Products for Mens Health and Wellness